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Our current - 2014 Project update 

August of 2014, the Wilmot Cancer Institute was awarded an additional $2,000,000 to further their Pancreatic Cancer Research. This is one of our seed projects and for many reasons became a special project to the foundation.

THANKS TO ALL...................YOU DID IT and YOU ROCKKKKKKKKKKKKK!

The Response of Cancer Cells to Chemotherapeutics

Human cells have quality-control mechanisms in place that survey their messenger RNAs ? the RNAs that produce cellular proteins ? in order to destroy those that pose a potential danger. One such pathway is called nonsense-mediated mRNA decay (NMD), which is a forte of our laboratory. We now have good evidence that NMD does double-duty, serving not only as a quality control mechanism but as a rheostat that contributes to cell death when cells are damaged. Many frontline chemotherapeutics (for example doxorubicin in its FDA approved form, marketed as Doxil) work by inducing damage to our genetic material, DNA, and in so doing, cause the death of rapidly dividing cells (a hallmark of cancer cells). We are studying NMD as a rheostat with funding from Edelman Gardner Seed Grant. We have discovered that damage to DNA temporarily inhibits NMD so as to induce the expression of our genetic material in a way that promotes cell death. It is this cellular suicide program that underlies the response of cancer patients to current therapeutics. By studying this program, we ultimately hope to define new chemotherapeutic targets.  

Your efforts are still working! Success from our last $50,000 donation

Hilton Foundation Funds Pancreatic Cancer Research

The Sally Edelman-Harry Gardner Cancer Research Foundation, a Hilton-based grassroots organization dedicated to finding cures for cancer, has awarded $50,000 grant to a pair of scientists working to better understand the mechanisms of pancreatic cancer.

Aram Hezel, M.D. 

Hartmut Land, Ph.D.

Hartmut ?Hucky? Land, Ph.D., chair of Biomedical Genetics and scientific director of Wilmot Cancer Center, and Aram Hezel, M.D., assistant professor of Medicine and gastrointestinal oncologist, received the funding to study a new potential target in pancreatic cancer that Land recently identified. Hezel will build upon Land?s laboratory findings to determine whether the new target is effective in treating the disease. Each year, about 43,000 Americans are diagnosed with pancreatic cancer, a deadly disease with few warning signs or symptoms until it has spread to other organs. Survival rates are poor. Pancreatic cancer has received significant attention in recent years after actor Patrick Swayze succumbed to the disease.

Any advances that we can make to improve the treatment of pancreatic cancer are a major step forward, says Richard I. Fisher, M.D., director of the Wilmot Cancer Center. It's wonderful to see this Foundation continue to partner with us to find cures. Land is an internationally recognized scientist who was among the first to discover that malignant cell transformation required multiple mutations in distinct cancer genes. Since then, he?s studied the cooperative nature of this process and the inner workings of cancer cell function.

Hezel has studied the genetics of pancreatic and biliary tract cancers and tested novel treatments in preclinical settings. His research, including clinical trials in pancreatic and hepatobiliary cancers, is published in oncology and science journals. The Edelman-Gardner Foundation has a nearly 40-year history of providing seed grants for novel cancer research. Scientists use the early results to secure additional grant funds.In one five-year period, the foundation awarded $250,000 to Wilmot Cancer Center scientists who were able to conduct research and use the early results to pursue additional funds from government agencies or other foundations. That quarter-million in research dollars was turned into $7.6 million in additional funding.

The Edelman-Gardner Foundation started in the early 1970s with a change jar at George Edelmans Arlington Restaurant and donations began flowing quickly when village postman Harry Gardner was diagnosed with cancer and later died in 1977. Shortly after that, Edelmans wife, Sally, was diagnosed with cancer and died in 1982. The commitment to funding research grew stronger and people organized golf, bowling and euchre tournaments, motorcycle and bicycle rides, book sales and bottle drives. Thousands of dollars were raised and Edelman and others formalized the effort in 1984 by creating the foundation. More than $800,000 has been raised to support research programs at the Wilmot

Cancer Center.

The Foundation Board of Directors includes Edelman, Karen Hermance, secretary, George Kauffman, treasurer, Sue Corey, and John Kwiatkowski.  

Edelman-Gardners Dr.'s Corner

The James P. Wilmot Cancer Center at the University of Rochester Medical Center is making great strides in the war on cancer. The support of the Sally Edelman and Harry Gardner Cancer Research Foundation allows our physicians and scientists to answer the many questions that cancer brings and enhances our oncologists' ability to provide the highest quality care to people with cancer in the Rochester and Western New York region.

Planting Seeds for Success

Funds from the Edelman/Gardner Cancer Research Foundation are being used by researchers - who bring scientific results from the bench to the bedside quickly. Their efforts are laying the groundwork for major federal funding to support further research into a number of areas in hematology - which is the science of treating cancers of the blood, such as leukemia and lymphoma.

Experimental Hermatology Program

Funds from the Edelman-Gardener foundation were distributed by the Experimental Hermatology Program (EHP) via a competitive grant process. Funds were awarded to support seven different collaborative research projects, with matching funds provided by the University of Rochester Medical Center. Collectively, Edelman-Gardner Funds contributed to the submission of five scientific papers and eight grant applications. To date, successful grant applications have resulted in about $1.4 Million in new research funds.

In Situ Antitumor Immunity and Effects of Radiation

(7/1/2006 - 6/30/2011)

The long term objective of this project is to investigate the interactions between tumor cells and host immune cells and to determine how hypoxia within the tumor alters cell infiltration and function. This recent grant is in the process of being funded for the amount of $250,000

Recently funded programsThese include A 3-D bioreactor system for long-term culture of hematologic samples, used to develop a novel three-dimensional bioreactor tissue culture system for the the culture of human peripheral lymphoid organ cells; Hematopoietic stem call and bone marrow stromal cell response to PTH, focus on the field of bone cell interactions with blood forming stem cells, data from this research has allowed the Wilmot Cancer Center to be recognized as a leader in hematopoietic-osteoblastic interactions. Investigations of protein kinase PKK in DLCL; data generated from this pilot fund will be used to submit another grant in the near future. Other programs: B-VCAm expression and function; Embryonic origin of the chondroclasts and osteoclasts; Cyclooxygenase expression and B-cell lymphoma/leukemia; and Farnesyl transferase and proteasome inhibition for leukemia therapy.

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Fundraisers in mind?????

Do you know anyone that wants to raise money for cancer??? We are always looking for ideas to raise money for research.

Anything you want to see in the website????? Let me know by sending me a note.

HFD

SEPTEMBER 2014

HFD has been a long partner and supporter of the Edelman - Gardner Caner Research Foundation.

The Board of Directors would like to give a huge thanks for their recent Donation from the Beer Tent Tip Jar . Your willingness to offer this during a time when you are raising your own funds is what makes the term "Home Town" such a special meaning. You truly our our own Home Town Heroes. we accept this donation in the name of your "brothers and sisters" that helped us raise money to fight this terrible disease. We also pledge to keep fighting because some have beat the odds. God Bless the Hilton Fire Department and all of those that risk their own life to save ours.

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